atrial natriuretic factor การใช้

• TGFbeta mediated activation of p38 MAPK decreases KLF15 permitting the upreg of myocardin and stimulate the expression of serum response factor target genes, such as atrial natriuretic factor eventually leading to left ventricular hypertrophy which often progresses to heart failure.
• Many vasoactive chemicals have been hypothesized as being involved in mediating the systemic hemodynamic changes, including atrial natriuretic factor, prostacyclin, thromboxane A2, and endotoxin . and octreotide ) leads to improvement in glomerular filtration rate ( which is a quantitative measure of kidney function ) in patients with hepatorenal syndrome, providing further evidence that splanchnic vasodilation is a key feature of its pathogenesis.
• Guanylate cyclase ( GC ) GTP to cGMP . Peptide hormones such as the atrial natriuretic factor activate membrane-bound GC, while soluble GC ( sGC ) is typically activated by nitric oxide to stimulate cGMP synthesis . sGC can be inhibited by ODQ ( 1H-[ 1, 2, 4 ] oxadiazolo [ 4, 3-a ] quinoxalin-1-one ).